![]() ![]() ![]() Klippel-Feil anomaly, or fusion of the atlas to the occipital may also be present.ĭown syndrome, or trisomy 21, is the most frequent of the chromosomal disorders and is frequently complicated by atlanto-occipital instability (AOI) and atlanto-axial instability (AAI). The more symptomatic clinical presentation frequently accompany the more severe inferior hindbrain herniation (Chiari 1.5), and have led to derivation of the term complex Chiari malformation to describe these patients with Chiari 1 malformation with complex features.īone malformations of the craniocervical junction occur in about 50% of the patients with Chiari I malformation, although the frequency ranges from 45 to 60%, depending on the series. The most important syndromes involving the craniovertebral junction include: Chiari I malformation, Down Syndrome, Achondroplasia and Mucopolysaccharidoses.Ĭhiari I malformation is a heterogeneous entity characterized by impaired cerebral spinal fluid (CSF) circulation at the level of the foramen magnum due to cerebellar tonsillar ectopia.Ĭraniovertebral junction anomalies (basilar invagination, platybasia, odontoid process retroflexion, third occipital condyle, abnormal clival-cervical angle) usually cause ventral cervicomedullary compression, contributing, together with the posterior compression that Chiari malformation causes, to the reduction of the space for the neuroaxis at the level of the bulbospinal junction. The image chosen for the Congress wish to convey this idea: the flight of the child over Milan, the busy city but also the multicultural town, is the ability to make you free from constraints, realizing your goal with the power of a constructive passion.Īgain, thank you all for being here and a warm welcome In this regard, I wish to acknowledge, with appreciation, all the speakers, experienced neuroradiologists and eminent experts from related disciplines.įinally, I believe that, in the internet addicted world, the true meaning of the Congress is the chance to meet together, the opportunity of an exchange of views and constructive discussions, with the effort to better face the difficulties of our daily work, so challenging in dealing with our young patients and, for this reason, so full involving. We tried to deal with all these issues in a multi-disciplinary approach, to enrich our knowledge in a broader and more comprehensive way. Attention to the methodological issues and continued investigations in this area are expected to result in further progress.įurthermore there will be a “challenging case” discussion session, becoming an appreciated tradition in our pediatric neuroradiology meetings. ![]() This technique has become a critical research tool for evaluating both normal and abnormal functional brain development and its clinical use is becoming more common in children. The second topic is dedicated to functional MRI in pediatric population. The development of this region is important for understanding the genesis of the numerous congenital malformations in this area. The first deals with the embriology and the normal and pathological conditions of the craniovertebral junction. The congress will be preceded by a short course concerning two topics. Furthermore a whole session is devoted to the eye movement disorders, including normal developmental anatomy of ocular motor nerves and their inborn and acquired pathological conditions, a wide range of unfamiliar pathologies during the developmental age. Other topics will be discussed, such as the broad spectrum of dysimmune encephalitis with a clinical perspective. These issues seem to us of great interest and relevance, thanks to the rapid improvement of the recent clinical applications from the basic research. Together with the scientific committee, our effort in deciding the scientific program was made with the purpose to investigate some topics that have engaged us in the recent years, in particular the normal brain development, the genetic aspects of some brain malformations and the new therapeutic perspective for the metabolic diseases, such as the gene therapy. So, thank you all for having attended and contributed to the success of this meeting. I can say that to meet you all here in Milan, for this event, is for me a real emotion and the opportunity of a personal growth. ![]() It is my great honour and pleasure to welcome you to the XII Italian Pediatric Neuroradiology Congress. ![]()
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